Decaffeinated coffee can improve brain energy metabolism in patients with type 2 diabetes

Brain dysfunction is a known risk factor for dementia and other neurodegenerative diseases such asAlzheimer's disease . Researchers at Mount Sinai School of Medicine found that caffeine- free coffee can improve brain energy metabolism in patients with type 2 diabetes . The study was published in the Journal of Nutritional Neurology. A team led by Giulio Maria Pasinetti, a professor of psychology and neurology at Mount Sinai School of Medicine and Ph.D. in Medicine, found that in experiments with mice, given a dose of caffeine-free coffee supplement before diabetes can improve insulin resistance. Caffeine-free coffee in diet-induced type 2 diabetes improves sugar utilization.

     After 5 months of supplementation with caffeine-free coffee, the genetic response of the mouse brain was assessed. They found that the brain can metabolize sugar more efficiently and use it to supply energy to brain cells. Patients with type 2 diabetes often have problems with neurocognition due to reduced cerebral glucose metabolism.

"The brain's energy metabolism damage is known to be closely related to cognitive decline with age and has a high risk of neurodegenerative diseases," Dr. Pasinett said. "This is the first evidence that a caffeine-free coffee pair Prevention and treatment of type 2 diabetes has a potential benefit from cognitive decline due to ageing and/or neurodegeneration."

  Coffee intake is not recommended for everyone because it is associated with cardiovascular risk such as blood cholesterol and elevated blood pressure, which can lead to heart disease , stroke and premature death. And these negative effects are due to the high caffeine content. The researchers were surprised to find evidence that coffee can be beneficial to the health of mice after caffeine removal. Dr. Pasinetti hopes to discover the mechanism by which caffeine-free coffee prevents disease and thus can be used for human dietary supplements. "Recent evidence suggests that cognitive impairment caused by Alzheimer's disease and other age-related neurodegenerative diseases may be traced to neuropathological changes that occurred decades ago, and it is important to develop preventive and therapeutic measures for such diseases. ," he said.